KISS1R (GPR54)

KISS1R (formerly the orphan receptor GPR54) is the G-protein-coupled receptor for the kisspeptins. It is expressed on GnRH neurons, and its activation is studied as an upstream trigger of the reproductive (HPG) axis.

Loss-of-function of KISS1R impairs pubertal maturation in genetic models, which established the receptor as a central node in reproductive-axis research. Described here as receptor pharmacology for laboratory reference only.